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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "Haplin" in publications use:'
type: software
license: GPL-2.0-or-later
title: 'Haplin: Analyzing Case-Parent Triad and/or Case-Control Data with SNP Haplotypes'
version: 7.3.2
identifiers:
- type: doi
  value: 10.32614/CRAN.package.Haplin
abstract: 'Performs genetic association analyses of case-parent triad (trio) data
  with multiple markers. It can also incorporate complete or incomplete control triads,
  for instance independent control children. Estimation is based on haplotypes, for
  instance SNP haplotypes, even though phase is not known from the genetic data. ''Haplin''
  estimates relative risk (RR + conf.int.) and p-value associated with each haplotype.
  It uses maximum likelihood estimation to make optimal use of data from triads with
  missing genotypic data, for instance if some SNPs has not been typed for some individuals.
  ''Haplin'' also allows estimation of effects of maternal haplotypes and parent-of-origin
  effects, particularly appropriate in perinatal epidemiology. ''Haplin'' allows special
  models, like X-inactivation, to be fitted on the X-chromosome. A GxE analysis allows
  testing interactions between environment and all estimated genetic effects. The
  models were originally described in "Gjessing HK and Lie RT. Case-parent triads:
  Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes.
  Annals of Human Genetics (2006) 70, pp. 382-396".'
authors:
- family-names: Gjessing
  given-names: Hakon K.
  email: hakon.gjessing@uib.no
preferred-citation:
  type: article
  title: 'Case-parent triads: Estimating single- and double-dose effects of fetal
    and maternal disease gene haplotypes'
  authors:
  - family-names: Gjessing
    given-names: H\aakon K
  - family-names: Lie
    given-names: Rolv Terje
  journal: Annals of Human Genetics
  volume: '70'
  issue: '3'
  year: '2006'
  start: '382'
  end: '396'
repository: https://hkgjess.r-universe.dev
commit: 91faded5cf91709d4e53f5ff73fa6b6c0e712d39
url: https://haplin.bitbucket.io
date-released: '2024-08-16'
contact:
- family-names: Gjessing
  given-names: Hakon K.
  email: hakon.gjessing@uib.no